Thermo-sensitive hydrogels for delivering biotherapeutic molecules: A review
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چکیده
منابع مشابه
Synthesis and Properties of Thermo-Sensitive Hydrogels Based on PVA/Chitosan/PNIPAAm
Thermo-sensitive hydrogels were prepared by graft copolymerization of Polyvenylalcohol and chitosan with N-Isopropylacrylamide via gamma radiation. Characterization of hydrogels such as DSC analysis and swelling and solubility tests in different ratios were investigated. DSC and solubility analysis showed chitosan and PVA and NIPAAm monomer were grafted via gamma radiation successfully. Results...
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B. Taşdelen*, N. Kayaman-Apohan, O. Güven and B. M. Baysal Chemistry Department, Çekmece Nuclear Research and Training Center, 34831, P.O. Box 1, Istanbul, Turkey Department of Chemistry, Marmara University, 81040 Göztepe/İstanbul, Turkey Department of Chemistry, Hacettepe University, 06532 Beytepe/Ankara, Turkey TUBITAK Marmara Research Center, Research Institute of Materials and Chemical Tech...
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today hydrogels are considered as the materials that are able to play important role in drug delivery systems. to design an effective hydrogel applicable network, mathematical modeling has a critical role. a successful drug delivery device relies not only on intelligent network design but also on accurate prior mathematical modeling of drug release profiles. in this study, the modeling of the i...
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Because of the short half-life, either systemic or local administration of bFGF shows significant drawbacks to spinal injury. In this study, an acellular spinal cord scaffold (ASC) was encapsulated in a thermo-sensitive hydrogel to overcome these limitations. The ASC was firstly prepared from the spinal cord of healthy rats and characterized by scanning electronic microscopy and immunohistochem...
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In the past few years, an increasing number of in situ-forming systems have been reported in the literature for various biomedical applications, including drug delivery, cell encapsulation, and tissue repair. There are several possible mechanisms that lead to in situ gel formation: solvent exchange, UV-irradiation, ionic cross-linkage, pH change, and temperature modulation. The thermosensitive ...
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ژورنال
عنوان ژورنال: Saudi Pharmaceutical Journal
سال: 2019
ISSN: 1319-0164
DOI: 10.1016/j.jsps.2019.08.001